Amazec Photonics secures €1.5 million Seed Round to develop new generation of circulatory and heart failure detection tech

15 February 2024

PhotonDelta backs photonics medtech that creates minimally invasive and more accurate monitoring solutions for diagnosing the performance of circulatory and cardiovascular systems

Oudkarspel, the Netherlands; 15 February 2024: Amazec Photonics, a photonics based medtech, has secured a €1.5 million Seed Round to develop its pioneering minimally invasive diagnosis devices.

The round was led by PhotonDelta – a cross-border growth accelerator and ecosystem of photonic chip technology organisations – with a number of private investors also contributing. The funding will be used to develop devices for clinical trials.

Cardiovascular diseases are the world’s leading cause of death accounting for 19 million deaths a year. This is in part due to the difficulty in diagnosing conditions which leads to delays in treatment. Amazec’s solution is a huge step forward in this battle, as it can enable much earlier and much more accurate diagnosis for minimal costs and complexity.

Amazec Photonics creates easy to apply cardiovascular monitoring tools. Existing solutions are complex, invasive and often inaccurate. The most common technique to measure cardiac output  is called thermodilution which involves injecting a known volume of liquid upstream of the heart and then measuring temperature changes downstream through specialised catheters inserted into the patient. This has several drawbacks including an inability to be used reliably during routine examination, large variation between measurements, a lack of sensitivity and high costs. Consequently, it often leads to late or misdiagnosis – severely impacting the outlook for patients.

In contrast, Amazec’s solution uses photonics-based technology to measure temperature changes to an unprecedented precision of 0.0001˚C (compared to current accuracy of 0.01˚C). The monitoring device is external which means there is no need to insert catheters. Multiple measurements can be made in real time which improves reliability – this is in contrast to the single measurement used in current methods.

Pim Kat, CEO of Amazec Photonics, said: “The number of people suffering from cardiovascular diseases has risen by 93% over the past 25 years and now impacts an estimated 550 million patients worldwide. Many of these people will die or suffer poor health outcomes because the tools we have to diagnose them simply aren’t good enough. Our solution can make a real difference because, not only does it vastly improve the accuracy of testing for cardiovascular disease, it is also much less invasive and simpler to use. This will substantially reduce costs and open the door to many more people being tested much more regularly.

“With this funding round we will be able to build ten prototypes and undertake extensive clinical trials with the intention of producing and selling devices across the EU by 2028.” 

Laurens Weers, CFO of PhotonDelta, said: “Amazec has leveraged the power of photonics to create a device that can make a profound impact on the world. Cardiovascular disease is one of the biggest health challenges we face and better diagnosis can be the key to saving millions of lives.

“We’re very proud to be a part of Amazec’s journey – we believe it has the capacity to become one of Europe’s most important medtechs and a standard bearer for a new generation of photonics-based technology.”

PhotonDelta’s investment in Amazec Photonics is the latest step in the organisation’s goal to create a world leading photonics industry in the Netherlands. PhotonDelta aims to help build 200 startups, create new applications for photonic chips and develop infrastructure and talent.

Amazec will begin clinical trials of its device at Catharina Hospital in Eindhoven this year, with an expansion to three other hospitals planned in 2025 with the aim of beginning full scale production and sale across the EU in 2028.

About Amazec

Amazec Photonics’ system is based on earlier R&D projects, executed by Technobis Fibre Technologies for ASML, FEI (high resolution FBG sensing) and AMC (hyperthermia sensor development). Amazec improved the integrated photonics chip and the stability of the  integrated photonics system. It also developed new algorithms for data processing required for transforming recorded raw data to useful signals and graphs.

Multiple IDCs measurements increase robustness and reliability of cardiac output compared to the single measurements used in current methods. This also enables calculation of CTBV, which is an important and highly relevant new clinical parameter that can be used to measure the amount of blood in the body.